Investing in Bio — Miracles (hopefully) built on molecules.

Harikesh Pushpapathan
2 min readJan 6, 2025

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Outsourcing my teachings to OpenAI

You don’t need a PhD in Microbiology and decades of c-suite experience to invest in bio — and walk away in the “green.” In fact, sometimes too much expertise can work against you. Seasoned veterans, for all their knowledge, are often trapped by their own experience — focusing on reasons to reject a proposition, overestimating risks, and clinging to familiar heuristics.

It’s easy to forget that breakthroughs often come from breaking the prototype. A decade ago, who would have imagined patients willingly paying over $1,000 out-of-pocket for a month’s supply of a drug? Similarly, could anyone have foreseen an AI-driven drug discovery platform raising $1 billion on launch? Back then, most of us thought moonshot ROIs only came from asset-led companies. The same too can be said about the resurgence of CNS, particularly Alzheimer’s assets.

Instead, success in biotech investing doesn’t require encyclopedic knowledge — it requires a curious mind and a little bit of courage to get you to a moderate level of expertise. That doesn’t mean Bio investing is easy to get right — it’s definitely not.

As Adam Grant puts it, “It is when people have moderate expertise in a particular domain that they are most open to radically creative ideas.”

Newbies are prone to false positives, sure, but seasoned pros are equally vulnerable to false negatives.

In any case — for the newbies, I’ve put together a primer on bio investing. One that I presented to last years UNSW AGSM Angel Investor Course. Enjoy and welcome any opinions.

Access Deck Here.

Credit few slides to Richard Murphey. Baybridge Bio is a killer resource.

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Harikesh Pushpapathan
Harikesh Pushpapathan

Written by Harikesh Pushpapathan

Investing in science, GP @ Stoic, moonlighting musician/artist.

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